Whether you live with depression today or worked through a difficult period in your life in the past, laughter can be the best medicine. When people are sad, helping bring a smile to their face can make all the difference in their day. Depression memes are not meant to ridicule people with depression, they’re meant to offer a small distraction and let people forget about any issues or problems in their lives, even if only for a second. It can affect adults at any time during their lives. Depression is no laughing matter and over 322 million people around the world live with some form of depression every day. First, let’s get one thing out of the way.